US-Ireland Centre-to-Centre Partnership Programme

A Science Founcation Ireland (SFI) funded US-Ireland Centre-to-Centre Partnership Programme Partnership in continuous manufacturing for nano-based drug products

The C2C collaboration provides a wonderful opportunity to exchange researchers at every level including academic staff, postdoctoral researchers and post-graduate students between the three centres, thereby exposing the researchers to alternative methodologies in other countries, generating co-authored publications and intellectual property and in doing so increasing the reputation of SSPC globally.

The partnership links together three of the world’s major pharmaceutical manufacturing and drug delivery research centres:
The Synthesis and Solid State Pharmaceutical Centre (SSPC) is a Global Hub of Pharmaceutical Process Innovation and Advanced Manufacturing, funded by Science Foundation Ireland and the Pharmaceutical industry.
The Centre for Structured Organic Particulate Systems (CSOPS) is a major Engineering Research Centre sponsored by the US National Science Foundation. The centre consists of four university sites (Rutgers, Purdue, NJIT, UPRM) and has 40 industry partners
The Centre for Pharmaceutical Sciences (CPS) at Queen’s University Belfast (QUB) is part  of the Institute of Precision Medicine and Pharmaceutical Sciences. This Institute is unique in the UK in that it is a medical research institute that is integrally linked with pharmaceutical sciences in order to promote and drive translational precision medicine.

Lead Centre and Principal Investigators (USA):
Fernando J. Muzzio is Distinguished Professor, Rutgers University and Director of CSOPS.
Zoltan K. Nagy holds the title of Professor, Purdue University, School of Chemical Engineering, West Lafayette, IN, USA, is Adjunct Research Prof., Loughborough Univ., Dep. of Chem. Engineering, UK and is the recipient of the prestigious European Research Council Fellowship (2011-2016).
Rohit Ramachandran is Associate Professor in the Department of Chemical and Biochemical Engineering, Rutgers University, and is the Project Leader in Process Control and Hardware integration at CSOPS.

Lead Principal Investigators and their associated Centre (NI):
Gavin Andrews is Professor (Chair of Pharmaceutical Engineering), School of Pharmacy, Queen’s University Belfast and has been an Industrial Fellow of the Royal Society in conjunction with Astra Zeneca.
David S. Jones is Pro-Vice-Chancellor (Education and Students) at the QUB and Professor of Biomaterials Sciences.
Colin P McCoy is Professor, School of Pharmacy, QUB and was previously a Reader in Pharmaceutics and a Royal Society University Research Fellow.

Project outputs:
• Proposal awarded: Padrela, L., Edlin, C., Ryan, K. M. SFI/NSF I-Corps@SFI Entrepreneurial Training Programme 2016 – ‘Continuous manufacturing method for the production of pharmaceutical drug nanoparticles dispersed in polymeric micron-sized granules’.
• Journal Article: Padrela, L. Zeglinski, Ryan, K. M. ‘An insight into the role of additives  in controlling polymorphic outcome: a CO2-antisolvent crystallization process of carbamazepine’, Crystal Growth and Design, under review.
• Poster presentation: Padrela, L. Long, B. Ryan, K. M. ‘Controlling amorphization versus crystallization of carbamazepine nanoparticles using a supercritical-assisted spray drying process’, 16th Annual Meeting of the American Institute of Chemical Engineers, San Francisco, USA, November  13-18, 2016.

Pictured in WASHINGTON, U.S., 16th March 2016: Doug Hausner, Industrial Liaison Officer, Rutgers University, Dr. Rohit Ramachandran, Rutgers School of Engineering, Zoltan Nagy, Professor of Chemical Engineering, Purdue University, Professor Séamus Davis, Prof. Mark Ferguson, Director General of Science Foundation Ireland, Prof. Gavin Walker, Bernal Chair of Pharmaceutical Powder Engineering, University of Limerick, Jon O’Halloran, SSPC General Manager and Prof. Kieran Hodnett, SSPC Scientific Director, University of Limerick. Picture: John Harrington.

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