PhD Position in Medicinal Carbohydrate Chemistry, School of Chemistry, National University of Ireland Galway. Applications are invited from suitably qualified candidates for a PhD position in the research group of Professor Paul Murphy, School of Chemistry, National University of Ireland Galway. This position is funded by Science Foundation Ireland and is available to start as soon as possible. The successful candidate will work under the direction of Professor Paul Murphy.
The successful candidate will work on a project concerned with the design and synthesis of glycomimetics. Specifically they will need to synthesize complex target molecules which are mimetics of sialyl lactose and related saccharides for evaluation against various targets such as galectin-8 and/or siglec-8 involved in asthma and some forms of inflammation/cancer. The project will involve producing desired compounds and purifying them to a high level to be distributed to international collaborators involved in structural studies on the synthetic glycomimetics and bioassays.
• Design and synthesis of mimetics of sialyl lactose for relevant biological targets involved in cancer and inflammation such as galectin-8 and siglec-8
• Candidates should have excellent communication and organizational skills; be highly motivated and passionate about developing new products; and have strong documentation, oral and interpersonal skills.
• PhD students normally enter the School of Chemistry structured programme
• Applicants should be aware that PhD students contribute to the teaching of undergraduates in the School of Chemistry at NUI Galway
• MSc completed in the area of synthetic organic chemistry, or MSc thesis submitted for examination before commencement of the project. In exceptional circumstances a BSc graduate may be recruited who has demonstrated outstanding performance in their undergraduate studies and who has obtained experience in using synthetic and analytical techniques. They should have at least an introductory knowledge of NMR spectroscopy in structure determination.
• The candidate must have interest in carbohydrate chemistry as well as in medicinal chemistry and synthesis.
• It will be an advantage to have an interest in computational methods and 3D structure as applied in medicinal chemistry.
• There may be the opportunity to carry out a placement at a leading international laboratory during the course of the study as part of the project
• Strong communication and interpersonal skills are required as it the ability to work well within a team
Scholarship: € 18,500 per annum with an additional contribution of €5,500 towards fees/levies etc as per SFI awards.
Start date: As soon as possible thereafter.
Preliminary applications can be made by email and must be sent to firstname.lastname@example.org and must contain ‘Glycomimetic PhD studentship’ in the subject line.
In your application please include
1. A covering letter which gives a detailed personal statement including your motivation for applying for this particular studentship
2. A pdf copy of an example of your own independent written research work (e.g. BSc thesis, MSc thesis) in the area of chemistry.
3. A full CV including the contact details of two referees. Include the list of any awards and evidence of excellent academic performance to date. Please detail any experience in the area of synthetic chemistry.
Closing date for receipt of applications is 5.00 pm on Wednesday June 27th.